Clinical Studies

Clinical Studies

Clinical Studies

Here is a list of clinical studies showing effects of music in people with epilepsy.

Huges JR et al, Clinical EEG 1998

Mozart's music significantly reduced epileptiform activity in epilepsy patients, including those with status epilepticus

Huges JR, Epil Beh 2001

Mozart's music decreased epileptiform activity in adult patients with status epilepticus

Lin LC et al, Epil Res 2010

Piano K.448, but not string K.448, reduced epileptiform discharges in epilepsy patients

Lin LC et al, Epil Behav 2011a

Mozart's music significantly (>50%) reduced seizure frequency in pediatric patients with refractory epilepsy

Lin LC et al, Epil Behav 2011b

One, two, and six months of listening to Mozart significantly reduced epileptiform discharges in children taking anti-epileptic drugs

Bodner M, et al PloS One 2012

Mozart's music significantly reduced seizures in adult epilepsy patients

Lin LC et al, Evid Based CAM 2012

Two sonatas, K.545 and K.448 were effective in reducing epileptiform discharges in the brain of epilepsy patients

Lin LC et al, Clin Neurophysiol 2013

Listening to Mozart reduces heart rate and activates parasympathetic nervous system

Lin LC et al, BMC CAM 2014

Seizure recurrence rate was significantly lower for the treatment group (listening to K.448 for ten minutes before bedtime)

Lin LC et al, Epil Res 2014

EEG can be used to predict beneficial effects of Mozart's music for epilepsy patients

Coppola G et al, Epil Behav 2015

Fifteen-day treatment with Mozart's music resulted in >50% reduction of seizures in 45% of patients

D'Alessandro et al, Psychiatr Danub 2017

Six-month treatment with Mozart's music resulted in 20% reduction of seizures in patients with refractory epilepsy


Clinical Studies

Behavioral therapy for people with epilepsy resulted in significant reduction of seizures. These interventions were also effective in people with refractory epilepsy. Here is a list of clinical studies showing effects of psychobehavioral interventions in people with epilepsy.

Gillham RA, Refractory epilepsy: an evaluation of psychological methods in outpatient management. Epilepsia (1990) 31:427-32

Significant reduction in seizure frequency in epilepsy patients during and six months after self-management intervention

Tieffenberg JA, et al. A randomized field trial of ACINDES: a child-centered training model for children with chronic illnesses (asthma and epilepsy). J Urban Health 2000, 77:280-97

Children with epilepsy had significantly fewer seizures in the behavioral-educational intervention group.

May TW, Pfafflin M, The efficacy of an educational treatment program for patients with epilepsy (MOSES): results of a controlled, randomized study. Modular Service Package Epilepsy. Epilepsia (2002) 43:539-49

Educational intervention resulted in significant reduction of seizure frequency in 19% of patients.

Lundgren T, et al. Evaluation of acceptance and commitment therapy for drug refractory epilepsy: a randomized controlled trial in South Africa—a pilot study. Epilepsia (2006) 47:2173-9

Behavioral intervention in drug-resistant epilepsy patients resulted in significant reduction in seizure frequency and duration in the treatment group.

Lundgren T, et al, Acceptance and Commitment Therapy and yoga for drug-refractory epilepsy: a randomized controlled trial. Epil Behav (2008), 13:102-8

Behavioral intervention was superior over yoga in reducing seizure frequency in epilepsy patients. 50% of patients became seizure-free after intervention.

McLaughlin DP, McFarland K, A randomized trial of a group based congitive behavior therapy program for older adults with epilepsy: the impact on seizure frequency, depression and psychosocial well-being. J Behav Med (2011) 34:201-207

Seizure frequency was significantly reduced (from average 6.33 seizures/month to average 1.39 seizures/month), as compared to control group in epilepsy patients.